L-GLUTAMINE
Wellness & Longevity
the essentials
What to Know About L-Glutamine
THE SCIENCE
How it works.
L-Glutamine is the most abundant amino acid in the body and is the primary energy source for enterocytes—the cells that form your intestinal barrier. By providing this direct fuel, L-Glutamine enables these cells to regenerate and repair the gut barrier more effectively, strengthening the “tight junction” proteins that regulate what passes into the bloodstream.
NEXT STEPS
Customize your service.
L-Glutamine can be used as a standalone supplement or woven into your personalized gut-healing plan within our HOSH Health Functional Medicine Program. We’ll determine the ideal dose, frequency, and combination of nutrients based on your unique history and lab results.
THE WHY
The core benefit.
Modern life, including chronic stress, poor diet, and medications, can rapidly deplete L-Glutamine reserves, leading to a weakened gut lining, increased permeability (leaky gut), bloating, and sensitivities. L-Glutamine replenishes this foundational nutrient, helping restore the gut’s integrity, soothe irritation, and support nutrient absorption.
YOUR JOURNEY
What you can expect.
We may incorporate L-Glutamine injections or supplements into your personalized gut-healing protocol, often paired with probiotics, microbiome testing, adrenal support, and anti-inflammatory nutrients. Patients commonly notice less bloating, reduced food sensitivities, improved bowel regularity, better post-meal comfort, and more stable energy.
L-Glutamine is the most abundant amino acid in the human body, playing a central role in intestinal integrity, immune function, and cellular repair. During times of stress—whether physical (exercise, infection), metabolic (inflammation), or emotional (elevated cortisol)—your body rapidly burns through glutamine, leaving the gut lining vulnerable.
L-Glutamine’s Unique Mechanism of Repair:
The unique power of L-Glutamine comes from its direct relationship with enterocytes, the cells that form the protective barrier of your small intestine. These cells rely on glutamine as their primary energy source, allowing them to regenerate efficiently. When glutamine is depleted, enterocytes cannot sustain the barrier, leading to:
Increased intestinal permeability (“leaky gut”)
Impaired absorption of nutrients
Activation of the immune system
Systemic inflammation
Glutamine also supports the tight junction proteins—the microscopic “locks” that regulate what can and cannot pass through the intestinal barrier.
Beyond the Gut: Systemic Benefits:
Immune Support: Glutamine supports lymphocytes and macrophages—cells critical for immune surveillance and pathogen defence (70% of your immune system is housed in the gut).
Metabolic Health: It contributes to glucose regulation, influencing gluconeogenesis and insulin sensitivity, often reducing sugar and carb cravings.
Physical Recovery: For athletes or those under chronic stress, supplementation is critical for muscle repair, quicker recovery, and reduced muscle soreness.
The evidence overwhelmingly shows that L-Glutamine is a foundational nutrient that supports the structure, function, and resilience of the gut barrier. Because a healthy gut dictates hormone balance, mood, metabolism, inflammation, and immunity, the benefits of this simple supplement extend to every system of your body. Start rebuilding your foundation for optimal health today.
The Foundational Role of L-Glutamine in Gut Health
a deeper dive
